| Interpretive Center | Address | City | State | Zip | Phone | |
| Arkansas Post National Memorial | 1741 Old Post Rd. | Gillett | AR | 72055 | 870-548-2207 | |
| Delta Culture Center | 141 Cherry St | Helena | AR | 72342 | 870-388-4350 | |
| Hampson Museum State Park | 2 Lake Dr. | Wilson | AR | 72395 | 870-655-8622 | |
| Lake Chicot State Park | 2542 Highway 25 | Lake Village | AR | 71653 | 870-265-5480 | |
| Lakeport Plantation | 601 Highway 142 | Lake Village | AR | 71653 | 870-265-6031 | |
| Mississippi County Historical & Genealogical Society Museum | 209 W. Hale | Osceola | AR | 72370 | 870-563-6161 | |
| Parkin Archeological State Park | 60 Highway, 184 N. | Parkin | AR | 72373 | 870-755-2500 | |
| White River National Refuge Visitor Center | 57 S. CC Camp Rd. | St. Charles | AR | 72140 | 870-282-8200 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Black Hawk State Historic Site | 1510 46th Ave. | Rock Island | IL | 61201 | 309-788-0177 | |
| Cahokia Mounds State Historic Site | 30 Ramey St. | Collinsville | IL | 62234 | 618-346-5160 | |
| Cairo Custom House Museum | 1400 Washington | Cairo | IL | 63401 | 618-734-1019 | |
| Fort de Chartres State Historic Site | 1350 State Highway 155 | Prairie du Rocher | IL | 62277 | 618-284-7230 | |
| Mississippi River Visitor Center | Lock & Dam #15, Building 328 | Rock Island | IL | 61204 | 309-794-5338 | |
| National Great Rivers Museum | 2 Lock & Dam Way | East Alton | IL | 62277 | ||
| Pere Marquette State Park Visitor Center | 13112 Visitor Center Ln. | Grafton | IL | 62037 | 618-786-3323 | |
| Pierre Menard State Historic Site & Fort Kaskaskia | 4320 Kaskaskia Rd. | Ellis Grove | IL | 62241 | 618-859-3031 | |
| Villa Kathrine / Friends of the Castle | 532 Gardner Expressway | Quincy | IL | 62301 | 217-224-3688 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Buffalo Bill Museum | 199 N. Front St. | LeClaire | IA | 52753 | 563-289-5580 | |
| Effigy Mounds National Monument | 151 Highway 76 | Ferry | IA | 52146 | 563-873-3491 | |
| George M. Verity Riverboat Museum | 101 Mississippi Dr. (Victory Park) | Keokuk | IA | 52632 | 319-524-4765 | |
| Hurstville Interpretive Center | 18670 63rd St. | Maquoketa | IA | 52060 | 563-652-3783 | |
| Iowa DNR - Guttenberg Fish Hatchery | 331 South River Park Dr. | Guttenberg | IA | 52052 | 319-252-1156 | |
| E.B. Lyons Interpretive Center / Mines of Spain Recreation Area | 8991 Bellevue Heights | Dubuque | IA | 52003 | 563-556-0620 | |
| Muscatine History & Industry Center | 117 W. Second St. | Muscatine | IA | 52761 | 563-263-1052 | |
| Nahant Marsh Education Center | 4220 Wapello Ave | Davenport | IA | 52802 | 563-323-5196 | |
| National Mississippi River Museum & Aquarium and National Rivers Hall of Fame | 350 E. 3rd St | Dubuque | IA | 52001 | 800-226-3369 | |
| Old Fort Madison | 811 Avenue E. | Fort Madison | IA | 52627 | 800-210-8687 | |
| Pine Creek Grist Mill | Wildcat Den State Park | Muscatine | IA | 52761 | 563-263-4818 | |
| Putnam Museum of History of Natural Science | 1717 W. 12 St. | Davenport | IA | 52804 | 563-324-1933 | |
| Toolesboro Mounds & Museum | 6568 Toolesboro Rd. | Wapello | IA | 52653 | 319-523-8381 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Columbus-Belmont State Park | 350 Park Rd. | Columbus | KY | 42032 | 270-677-2327 | |
| Wickliffe Mounds State Historical Site | 94 Green St. | Wickliffe | KY | 42087 | 270-335-3681 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| The Historic New Orleans Collection | 533 Royal St. | New Orleans | LA | 70130 | 504-523-4662 | |
| Jean Lafitte National Historical Park & Preserve | 419 Decatur St. | New Orleans | LA | 70130 | 504-589-2133 | |
| Louisiana State Museum | 751 Chartres St. | New Orleans | LA | 70116 | 504-568-6968 | |
| LSU Rural Life Museum and Windrush Gardens | 4650 Essen Lane | Baton Rouge | LA | 70898 | 225-765-2437 | |
| Plaquemine Lock State Historic Site | 57730 Main St. | Plaquemine | LA | 70764 | 225-687-7159 | |
| Port Hudson State Commemorative Area | 236 Highway 61 | Jackson | LA | 70748 | 888-677-3400 | |
| Poverty Point State Historic Site | 6859 Highway 577 | Pioneer | LA | 71266 | 888-926-5492 | |
| West Feliciana Historical Society Museum | 11757 Ferdinand St. | St. Francisville | LA | 70775 | 225-635-6330 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Forest History Center / Minnesota Historical Society | 2609 County Rd., 76 | Grand Rapids | MN | 55744 | 218-327-4482 | |
| Historic Fort Snelling | 200 Tower Ave. | St. Paul | MN | 55111 | 612-726-1171 | |
| Itasca State Park - Jacob Brower Visitor Center | 36750 Main Park Dr. | Park Rapids | MN | 56470 | 218-699-7251 | |
| Mill City Museum | 704 Sound 2nd St | Minneapolis | MN | 55401 | 612-341-7555 | |
| Minnesota History Center | 345 W Kellogg Blvd. | St. Paul | MN | 55102 | 651-259-3000 | |
| Minnesota Marine Art Museum | 800 Riverview Dr | Winona | MN | 55987 | 507-474-6626 | |
| National Eagle Center | 152 Main St | Wabasha | MN | 55981 | 651-565-4989 | |
| The Science Museum of Minnesota / Mississippi River Visitor Center | 345 W. Kellogg Blvd | St. Paul | MN | 55102 | 651-221-9444 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| The Delta Blues Museum | 1 Blues Alley | Clarksdale | MS | 38614 | 662-627-6820 | |
| Natchez Visitor Reception Center | 640 South Canal St. | Natchez | MS | 39120 | 601-446-6345 | |
| River Road, Queen Welcome Center | Highway 82 West at Reed Rd. | Greenville | MS | 38704 | 662-332-2378 | |
| Tunica RiverPark Museum | One River Park Dr. | Tunica | MS | 38664 | 866-517-4837 | |
| Vicksburg National Military Park | 3201 Clay St | Vicksburg | MS | 39183 | 601-636-0583 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Cape Girardeau Conservation Nature Center | 2289 County Park Dr. | Cape Girardeau | MO | 63701 | 573-290-5218 | |
| City of Clarksville Visitor Center | 111 Howard St. | Clarksville | MO | 63336 | 573-242-3336 | |
| Howard & Joyce Wood Education & Visitor Center at Columbia Bottom Conservation Area | 801 Strodtman Rd. | St. Louis | MO | 63138 | 314-877-6014 | |
| Jefferson National Expansion Memorial (The Gateway Arch & Old Courthouse) | 11 N. 4th St. | St. Louis | MO | 63102 | 314-655-1700 | |
| Mark Twain Museum Interpretive Center | 120 N. Main St. | Hannibal | MO | 63401 | 573-221-9010 | |
| New Madrid Historical Museum | 1 Main St. | New Madrid | MO | 63869 | 573-748-5944 | |
| Ste. Genevieve Welcome Center | 66 S. Main St. | Ste. Genevieve | MO | 63670 | 800-373-7007 | |
| Trail of Tears State Park | 429 Moccasin Springs | Jackson | MO | 63755 | 573-290-5268 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| C.H. Nash Museum at Chucalissa | 1987 Indian Village Dr. | Memphis | TN | 38109 | 901-785-3160 | |
| Mississippi River Museum at Mud Island River Park | 125 N. Front St. | Memphis | TN | 38103 | 800-507-6507 | |
| Reelfoot Lake State Park Visitor Center | 2595 State Route 21E | Tiptonville | TN | 38079 | 731-253-9652 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Fort Crawford Museum | 717 S. Beaumont Rd. | Prairie du Chien | WI | 53821 | 608-326-6960 | |
| Great River Road Visitor & Learning Center | 200 Monroe St. | Prescott | WI | 54021 | 715-262-0104 | |
| Riverside Museum | 410 Veterans Memorial Dr. | La Crosse | WI | 54601 | 608-782-1980 | |
| Stonefield State Historic Site | 2195 Hwy VV | Cassville | WI | 53806 | 608-725-5210 | |
| Potosi Brewing Company | 209 South Main St. | Potosi | WI | 53820 | 608-763-4002 | |
| Villa Louis | 521 N. Villa Louis Rd. | Prairie du Chien | WI | 53821 | 608-326-2721 |
