| Interpretive Center | Address | City | State | Zip | Phone | |
| Arkansas Post National Memorial | 1741 Old Post Rd | Gillett | AR | 72055 | 870-548-2207 | |
| Delta Culture Center | 141 Cherry St | Helen | AR | 72342 | 870-388-4350 | |
| Hampson Museum State Park | Wilson | AR | 72395 | 870-655-8622 | ||
| Lake Chicot State Park | 2542 Highway 25 | Lake Village | AR | 71653 | 870-265-5480 | |
| Lakeport Plantation | 601 Highway 142 | Lake Village | AR | 71653 | 870-265-6031 | |
| Parkin Archeological State Park | Parkin | AR | 72373 | 870-755-2500 | ||
| White River National Refuge Visitor Center | 57 South CC Camp Rd | St. Charles | AR | 72140 | 870-282-8200 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Black Hawk State Historic Site | 1510 46th Ave. | Rock Island | IL | 61201 | 309-788-9536 | |
| Cahokia Mounds State Historic Site | 30 Ramey St | Collinsville | IL | 62234 | 618-346-5160 | |
| Cairo Custom House Museum | 1400 Washington | Cairo | IL | 63401 | 618-734-1019 | |
| Fort de Chartres State Historic Site | 1350 State Highway 155 | Prairie du Rocher | IL | 62277 | 618-284-7230 | |
| Mississippi Visitor Center – Arsenal Island | Lock & Dam #15 | Rock Island | IL | 61204 | 800-645-0248 | |
| National Great River Museum | 2 Lock & Dam Way | East Alton | IL | 62024 | 877-462-6979 | |
| Pere Marquette State Park Interpretive Center | Route 100 W | Grafton | IL | 62037 | 618-786-3323 | |
| Pierre Menard State Historic Site & Fort Kaskaskia | 4320 Kaskaskia Rd | Ellis Grove | IL | 62241 | 618-859-3031 | |
| Villa Kathrine | 532 Gardner Expressway | Quincy | IL | 62306 | 217-224-3688 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Effigy Mounds National Monument | 151 Highways 76-10 mi south of Harpers | Ferry | IA | 52146 | 563-873-3491 | |
| Iowa DNR- Guttenberg Fish Hatchery | 331 South River Park Dr | Guttenberg | IA | 52052 | 563-252-1156 | |
| Mines of Spain/E.B. Lyons Interpretive Center | 8991 Bellevue Heights | Dubuque | IA | 52003 | 563-556-0620 | |
| Mississippi Valley Welcome Center | 900 Eagle Ridge Rd | LeClaire | IA | 52753 | 563-322-3911 | |
| Muscatine History & Industry Center/Pearl Button Museum | 117 W. Second St | Muscatine | IA | 52761 | 563-263-1052 | |
| Nahant Marsh Education Center | 4221 Wapello Ave | Davenport | IA | 52802 | 563-323-5196 | |
| National Mississippi River Museum & Aquarium and National Rivers Hall of Fame | 350 E. 3rd St | Dubuque | IA | 52001 | 800-226-3369 | |
| Old Fort Madison | 101 Mississippi Dr., (Victory Park | Keokuk | IA | 52632 | 800-383-1219 | |
| Putnam Museum of History of Natural Science | 1717 West 12 St | Davenport | IA | 52804 | 563-324-1933 | |
| The George M. Verity Riverboat Museum | P.O. Box 400 | Keokuk | IA | 52632 | 319-524-4765 | |
| Toolesboro Indian Mounds & Museum | Highway 99 | Wapello | IA | 52653 | 319-523-8381 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Carlisle County Museum | 140 St Rt 123, Suite B | Bardwell | KY | 42023 | ||
| Columbus-Belmont State Park | 350 Park Rd | Columbus | KY | 42032 | 270-335-3681 | |
| Wickliffe Mounds State Historical Site | 94 Green St | Wickliffe | KY | 42087 | 270-335-3681 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Jean Lafitte National Historical Park & Preserve | 419 Decatur St | New Orleans | LA | 70130 | 504-589-2133 | |
| Louisiana State Museum | 751 Chartres St | New Orleans | LA | 70116 | 504-568-6968 | |
| LSU Rural Life Museum and Windrush Gardens | 4650 Essen Lane | Baton Rouge | LA | 70898 | 225-765-2437 | |
| Plaquemine Lock State Historic Site | 57730 Main St | Plaquemine | LA | 70764 | 877-987-7158 | |
| Port Hudson State Commemorative Area | 236 Highway 61 | Jackson | LA | 70748 | 888-677-3400 | |
| Poverty Point State Historic Site | 6859 Highway 577 | Pioneer | LA | 71266 | 888-926-5492 | |
| The Historic New Orleans Collection | 533 Royal St | New Orleans | LA | 70130 | 504-523-4662 | |
| West Feliciana Historical Society Museum & Tourist Center | 11757 Ferdinand St | St. Francisville | LA | 70775 | 800-789-4221 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Forest History Center | 2609 County Rd., 76 | Grand Rapids | MN | 55744 | 218-327-4482 | |
| Historic Fort Snelling | Highways 55 and 5 | Minneapolis | MN | 55111 | 612-726-1171 | |
| Itasca State Park-Mary Gibbs Mississippi Headwaters Center | 36750 Main Park Dr. | Park Rapids | MN | 56470 | 218-266-2100 | |
| Mill City Museum | 704 Sound 2nd St | Minneapolis | MN | 55401 | 612-341-7555 | |
| Minnesota History Center | 345 W Kellogg Blvd. | St Paul | MN | 55102 | 800-657-3773 | |
| Minnesota Marine Art Museum | 800 Riverview Dr | Winona | MN | 55987 | 507-474-6626 | |
| National Eagle Center | 152 Main St | Wabasha | MN | 55981 | 651-565-4989 | |
| The Science Museum of Minnesota/ NPS Mississippi River Visitor Center | 345 W. Kellogg Blvd | St Paul | MN | 55102 | 651-221-9444 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Natchez Visitor Reception Center | 640 South Canal St | Natchez | MS | 39120 | 800-647-6724 | |
| River Road, Queen Welcome Center | Highway 82 West at Reed Rd | Greenville | MS | 38704 | 800-467-3582 | |
| The Delta Blues Museum | 1 Blues Alley | Clarksdale | MS | 38614 | 662-332-2378 | |
| Tunica RiverPark Museum | One River Park Dr | Tunica | MS | 38664 | 866-517-4837 | |
| Vicksburg National Military Park | 3201 Clay St | Vicksburg | MS | 39183 | 601-636-0583 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Cape Girardeau Conservation Campus Nature Center | 2289 County Park Dr | Cape Girardeau | MO | 63701 | 573-290-5218 | |
| Columbia Bottom Conservation Area Nature Center | 801 Strodtman Rd | St. Louis | MO | 63138 | 314-877-6014 | |
| Great River Road Interpretive Center | 66 South Main St | Sainte Genevieve | MO | 63670 | 573-883-7097 | |
| Jefferson National Expansion Memorial (The Arch) | 11 N. 4th St | St Louis | MO | 63102 | 341-655-1700 | |
| Mark Twain Boyhood Home and Museum | 208 Hill St | Hannibal | MO | 63401 | 573-242-3132 | |
| New Madrid Historical Museum | 1 Main St | New Madrid | MO | 63869 | 573-748-5944 | |
| Trail of Tears State Park | 429 Moccasin Springs | Jackson | MO | 63755 | 573-290-5268 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Chucsalissa Museum | 1987 Indian Village Dr | Memphis | TN | 38109 | 901-785-3160 | |
| Mississippi River Museum at Mud Island | 125 N. Front St | Memphis | TN | 38103 | 800-507-6507 | |
| Reelfoot lake State Park Visitor Center | 120 State Route 213 | Tiptonville | TN | 38079 | 800-250-8617 |
| Interpretive Center | Address | City | State | Zip | Phone | |
| Fort Crawford Museum | 717 S. Beaumont Rd | Prairie du Chien | WI | 53821 | ||
| Great River Road Visitors & Learning Center at Freedom Park | 200 Monroe St | Prescott | WI | 54021 | 715-262-0104 | |
| Riverside Museum | 410 Veterans Memorial Dr., Riverside Park | La Crosse | WI | 54601 | 608-782-1980 | |
| Stonefield State Historic Site | 2195 Hwy V V | Cassville | WI | 53806 | 608-725-5210 | |
| The Potosi Brewing Company | 209 South Main St | Potosi | WI | 53820 | ||
| Villa Louis | 521 N. Villa Louis Rd | Prairie du Chien | WI | 53821 | 608-326-2721 |
